Each mL contains:
● Nepafenac – 0.3% w/v
● Benzalkonium Chloride – NIL (BKC-Free)
● Sterile Aqueous Vehicle – q.s.
NAVIRES-OD™ is a clear to slightly yellow-orange sterile ophthalmic suspension free from benzalkonium chloride (BKC), making it gentle for long-term ocular use.
As directed by the physician.
Typical dosage: One drop once daily beginning 1 day before cataract surgery, continued on the day of surgery, and for the first 14 days postoperatively.
Indications
● Prevention and treatment of post-operative pain and inflammation associated with cataract surgery.
● Suitable for sensitive eyes due to its BKC-free formulation.
Pharmacodynamics
Nepafenac is a non-steroidal anti-inflammatory drug (NSAID) that penetrates the cornea and is converted into Amfenac, a potent COX inhibitor. It:
● Inhibits prostaglandin production
● Reduces ocular inflammation
● Alleviates pain following cataract surgery
● Rapidly converted into Amfenac in ocular tissues
● Maximum concentrations reached within 0.5–2 hours
● Eliminated through aqueous humor with a half-life of approximately 0.5 hours
● Very low systemic exposure
● Once-daily dosing for patient convenience
● Preservative-free (BKC-Free) formulation minimizes risk of ocular surface damage
● Clinically proven for post-surgical pain relief and anti-inflammatory action
● Hypersensitivity to Nepafenac or any NSAIDs
● Patients with known bleeding tendencies or active ocular infections
● Avoid use in patients with known hypersensitivity to NSAIDs
● Prolonged use may delay healing
● Should not be used while wearing contact lenses
● Use with caution in patients with diabetes, rheumatoid arthritis, or complicated ocular
surgeries
● Should be avoided in pregnant women unless clearly necessary
● Use during lactation only if the potential benefit justifies the potential risk
● Use caution with other NSAIDs or corticosteroids
● Allow at least 5 minutes between different ophthalmic products
Possible adverse effects include:
● Foreign body sensation
● Eye pain or irritation
● Blurred vision
● Increased intraocular pressure
● Corneal edema or inflammation (rare)
● Store in a well-ventilated area below 25°C
● Protect from light
● Keep out of reach of children
● Use within 30 days after opening
NAVIRES-OD™ is available in a sterile 5 ml pack in an LDPE vial with outer carton and leaflet.
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